Main Article Content
A series of halo substituted isoxazole derivatives, 3-(halo substituted anilino) -5-(substituted aryl)-isoxazoles (HAI-1, HAI-2 and HAI-3) were synthesized by both conventional and microwave synthesis process from acetanilide or its derivative. 3-substituted phenyl-1-anilino or 1-substituted anilino-2-propene-1-ones were synthesized by reaction of acetanilide or its derivative compounds in ethanol with aldehyde (or) substituted aldehyde. 3-[halosubstituted anilino]-5-[substituted aryl] isoxazoles were synthesized by refluxing -substituted phenyl-1-anilino or 1-substituted anilino-2-propene-1-ones with hydroxylamine hydrochloride (0.00014 mole) and sodium acetate (0.08 mole) in ethanol. The structures of the synthesized various isoxazole have been characterized by using elemental analysis, Infrared,1 H-NMR spectroscopy and further supported by Mass spectroscopy. All the products have been screened for their antibacterial activity towards Gram-positive and Gram-negative bacterial strains and antifungal activity at a concentration of 30, 60 and 90 µg/ml. It was exposed that the compounds showed inspiring antibacterial and antifungal activity compared to the used reference standard.