Pamam Dendrimer-Based Nano carriers for Solubility Enhancement of Etoricoxib

Abstract

One way to achieve optimal delivery mechanisms for poorly soluble pharmaceuticals is to use PAMAM dendrimers. PAMAM dendrimers offer a variety of functional groups that can be used to aid in solubility by way of hydrogen bonds, electrostatic forces, encapsulation, or other means. In addition, PAMAM dendrimers contain numerous voids that may also assist with solubility through the aforementioned means PAMAM dendrimers can also be used effectively as a nanocarrier system to increase the solubility or bioavailability of hydrophobic drug molecules. PAMAM dendrimer drug delivery systems will be discussed in this review article, including their effect on enhancing solubility and pharmacokinetics of the drug Etoricoxib. To illustrate this point, the article will provide information about Etoricoxib’s physicochemical properties, challenges encountered when developing drug formulations that will maximize Etoricoxib’s therapeutic benefit, general characteristics associated with the construction of PAMAM dendrimers (including generation), how PAMAM dendrimers interact with drugs, previously published studies describing the use of dendrimers to facilitate solubility for poorly soluble drugs, and formulation approaches for creating Etoricoxib-dendrimer complexes and characterizing those complexes.