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A Six- month prospective interventional study on prophylactic administration of antibiotics and risk of surgical site infections (SSI), was conducted at the department of general surgery at Malla Reddy hospital. Surgical Site Infections were classified according to American Centre for Disease Control (CDC) criteria and identified by active bedside surveillance and post discharge follow up.  Antibiotics were selected according to Indian Council Of Medical Research (ICMR), American Society Of Health-System Pharmacists (ASHP), Center For Disease Control And Prevention Guideline for prevention of surgical site infection, 2017, WHO Surgical Site Infection Prevention Guidelines and surgeon’s point of view. It was studied for a period of one month followed by randomization of patients into two groups. GROUP A - Administration of antibiotics by Surgeon’s frame of medications. GROUP B - Administration of antibiotics according to evidence based guidelines. In first group, 13 combinations of antibiotics were prescribed, out of which the combination of Cefotaxime and Amoxicillin were majorly prescribed for duration of 7 Days. In second group, cefotaxime was majorly prescribed (80%)And all the antibiotics were stopped within 24 hours of surgery in group .we conclude that the timing of administration of antibiotics plays an important role in the prevention of SSI rather than multiple post operative doses. The administration of an antibiotic as a peri dose in longer surgeries ensures that t1/2 of the antibiotic is maintained. We also conclude that the entire teams of health care professionals at every step of hierarchy are responsible for taking precautions in the prevention of infection.


(SSI) Surgical site infection, Nosocomial Infections Surveillance (NNIS), System, Society for Healthcare Epidemiology of America (SHEA), Institutional Human Ethics Committee (IHEC), Infectious Diseases Society of America (IDSA).

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