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Abstract

Piroxicam is a nonsteroidal anti-inflammatory drug, which result in inhibition of the enzyme cyclooxygenase (COX). The aim of this study is to formulate and evaluate oral disintegrating tablets (ODTs) of Piroxicam to achieve rapid dissolution, absorption and further improving the bioavailability of the drug. The oral disintegrating tablets were prepared by using Primojel, Ac -di-Sol and Polyplasdone XL10 by direct compression method. Taste masking was done by Sweetening agents. Drug -polymer complex was then formulated into orally disintegrating tablets by direct compression by using different concentrations of super disintegrants. Tablets were evaluated for weight variation, thickness, hardness, friability, drug content, in vitro disintegration time and in vitro dissolution studies. The formulation containing 40mg Primojel showed faster disintegration within 15 Seconds.

Keywords

Piroxicam , Oral disintegrating Tablets Primojel Ac-di-Sol Polyplasdone XL10

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