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  1. Detail case presentation on pharmacology and therapy of gout Download Article

    M.Vanitha Sree, M.Swetha, D.Suma Latha, R.Sagar
    • Article Type: Research Article
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    • Pages (21-28)
    • No of Download = 45

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    Gout is a metabolic disorder characterised by precipitation of uric acid crystals especially in smaller bones of feet (commonest is metatarso - phalangeal joint in great toe), joints, kidney, subcutaneous tissue. The major symptoms of gout include severe attacks of pain, lingering discomfort, inflammation, redness and limited range of movement. Gout is caused due to deposition of uric acid which is a metabolic product of purines which naturally occurs in our body. Normally uric acid dissolves in our body but when the concentration increases above 6mg/dl because of improper functioning of kidney or over production of it by our body causes its deposition in the joints. People usually experience gout signs and symptoms again and again but medications can help prevent the gout attacks. If it’s left untreated it may cause erosion, stiffness and destruction of the joint. Therefore, there is an urgent need to explore effective diagnostic approaches to catch and better treat the disease before it worsens. Usually joint fluid test, blood test, X-ray imaging, ultra sound, dual energy CT scan are used for diagnosis. Joint fluid and blood test help in finding the uric acid crystals under microscope whereas the X-ray ultra sound examines soft tissues and bone. Gout can be controlled by medication by either reducing pain on attack or reducing the uric acid build up. NSAIDS are given for reducing the pain and inflammation and if NSAIDS are taken in 1st 24hrs then it helps in shortening the attack. In sever cases uricosuric drugs or uric acid synthesis inhibitors are used to prevent the uric acid production.

  2. Screening of ethanolic extract of artocarpus heterophyllus l. bark for anthelmintic activity Download Article

    Dr.S.Muthukumar, Dr.S.Selvakumar, S.Dharmaraj Santhosam, K.Seenikani
    • Article Type: Research Article
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    • Pages (29-37)
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    The aim of the present study was to evaluate anthelminthic activity of crude ethanolic extract of Artocarpus heterophyllus bark by using test worm. Albendazole was included as standard.  The results indicated that ethanolic extract was significantly paralysis and also caused death of worm in short time compared to that of the standard drug. Various concentrations like 5, 10, 15, 25, 50 mg/ml of ethanolic extract was tested,   against the paralysis and death, but 50mg/ml showed less time (03.88±0.19) for paralysis and (23.57±0.38) for death of worm. So we conclude that the traditional use of Artocarpus heterophyllus has anthelminthic activity and further studies are suggested to isolate the active principles which are responsible for the activity. The observations showed the anthelminthic activity of Artocarpus heterophyllus by paralysis and death of earth worms.

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