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  1. Formulation, development and in vitro evaluation of floating tablet of tramadol hydrochloride Download Article

    Ch.Madhava Reddy, Dr.N.Sriram, Raju Manda
    • Article Type: Research Article
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    • Pages (246-250)
    • No of Download = 131

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    Floating drug delivery systems have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system. Tramadol Hydrochloride effervescent sustained release tablets were developed in eight different formulations (TF1 to TF8) by employing different grades of polymers and effervescent agents such as sodium bicarbonate and citric acid. The formulations were evaluated for various physical parameters, dissolution parameters and drug released mechanisms. TF8 formulation showed maximum floating time of 12 hours and gave slow and maximum drug release of Tramadol Hydrochloride spread over 12 hours and whereas Tramadol Hydrochloride released from marketed tablet was rapid and maximum within 8.3 hours.

  2. International conference on harmonisation of technical requirements for registration guideline for good clinical practice Download Article

    Pedapaka Uday, Kanuganti.Madhukar, Ch.Madhava Reddy
    • Article Type: Research Article
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    • Pages (251-264)
    • No of Download = 104

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    Good Clinical Practice (GCP) is an international ethical and scientific quality standard for designing, conducting, recording and reporting trials that involve the participation of human subjects. Compliance with this standard provides public assurance that the rights, safety and well-being of trial subjects are protected; consistent with the principles that have their origin in the Declaration of Helsinki, and that the clinical trial data are credible. Drug reviewers in regulatory agencies around the world bear the responsibility of evaluating whether the research data support the safety, effectiveness and quality control of a new drug product to serve the public health. Every country has its own regulatory authority, which is responsible to enforce the rules and regulations and issue the guidelines to regulate the marketing of the drugs. As positive safety and efficacy data are gathered, the number of patients typically increases. Clinical trials can vary in size, and can involve a single research entity in one country or multiple entities in multiple countries. 

  3. Formulation and in-vitro evaluation of metformin-glipizide sustained release matrix tablets Download Article

    R.Pranitha
    • Article Type: Research Article
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    • Pages (265-269)
    • No of Download = 97

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    Sustained release formulation of Metformin-Glipizide presents significant challenges due to its poor inherent compressibility, high dose and high water solubility. Sustained release matrix tablets of Metformin-Glipizide were formulated using different concentration of Guar gum, Xanthan gum, and Chitosan polymers. The formulated powder blends were evaluated for angle of repose, bulk density, true density, compressibility index and total % porosity. The tablets were subjected to hardness, friability, % weight variation and % drug content. In vitro release studies were carried out at pH 1.2 and pH 7.2 using the dissolution test apparatus USP. The formulated powder blends and tablets showed satisfactory results from selected formulation. 

  4. 100% WHEY (LACTOWHEY): A premium protein Sourced from cows, not treated with any harmones to help build muscles, spark recovery, supports the immune system Download Article

    Govind Shukla, Neha S.Giri, C.J. Sampath Kumar
    • Article Type: Research Article
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    • Pages (270-280)
    • No of Download = 54

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    Protein is critical to build and maintain muscle, recover post-workout, support immune function, stabilize energy, and help you feel fuller, longer. 100% WHEY (LACTOWHEY), whey protein concentrate is a unique blend of amino acids has been shown to be more effective in elevating performance compared to other forms of protein. 100% WHEY (LACTOWHEY): Whey protein concentrate has been well-studied in recent years and shown to provide optimal benefits as part of  post-workout recovery.

    100% WHEY (LACTOWHEY), whey protein is sourced from cows that haven't been treated with hormones. It contains no artificial colors or sweeteners, no carrageenan, and no gluten. This review summarises the current available scientific literature regarding the effect of LACTOWHEY, A premium protein to help build muscles, spark recovery, supports the immune system.

  5. Formulation and In-Vitro evaluation of 1, 4 dihydropyridine calcium channel blocker nimodipine in to oral disintegrating tablets Download Article

    Dr P Shashidhar, Dr D Ramakrishna, Dr M Sunitha, Ms Hana Jabri
    • Article Type: Research Article
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    • Pages (281-304)
    • No of Download = 21

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    In the present intended research work Nimodipine a calcium channel blocker was selected for preparation of oral disintegrating tablets for immediate action. 20 trials were attempted for optimizing the formula by using supra-disintegrating agent’s crosscarmellose sodium, Crosspovidone, Sodium Starch Glycolate with varying concentrations. In-vitro evaluation parameters 20 formulations were evaluated off which the range is of wetting time was between 16.075 to 57.33 sec, water absorption studies range from 59.23 to 67.54 percent, disintegrating time was between 166 to 171 sec, where as dispersion time was found to be 3.66 to 259.83 sec. In case of drug release the rate of drug release was drastically increased as concentrations of supra disintegrants are increased as from formulations F1 to F4 presence of cross povidone, the drug release was found to be 95.78 to 98.99, from F5 to F8 crosscarmellose sodium and drug release was found to be 89.53 to 95.43, from F9 to F12 with sodium starch glycolate 89.4 to 92.8 and from F13 to F16 in the combination of crosscarmellose sodium and Crosspovidone the drug release 94.5 to 96.38 and form F17 to F20 combination of Crosspovidone and Sodium Starch Glycolate release was from 88.56 to 94.52. Based on all the evaluation parameters formulation F20 was finalized and considered the objectives of the project were fulfilled.

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