Articles

  1. WELLIA-R tablets; helps to protect brain tissue in cerebral edema Download Article

    Govind Shukla, Nagalakshmi Yaparthy, D.Sruthi Rao, C.J. Sampath Kumar
    • Article Type: Research Article
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    • Pages (1-4)
    • No of Download = 77

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    Boswellia serrate extract in Wellia- R gained significant importance in treatment of cerebral edema in patients with brain tumors, colon cancer, lung cancer, blood cancer, skin cancer, breast cancer, renal cancer, fibro sarcoma, prostate cancer and pancreatic cancer. The medicinal properties of Boswellia serrate extract in Wellia- R have been known and utilized since antiquity. Its current potential as an anti inflammatory and anticancer agent are being investigated and hold great promise. This article reviews the current available scientific literature regarding the effect of wellia-R tablets, from Boswellia serrate extract that Provides long lasting cerebral protection in brain tumor patients

  2. Method development and validation of simultaneous estimation of paracetamol & tramadol HCL in bulk and dosage form Download Article

    Tirunagari Rahul Swamy, K.Mohan, B.R.Sarath Kumar, Dr. Naseem
    • Article Type: Research Article
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    • Pages (05-28)
    • No of Download = 73

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    A drug may be defined as a substance meant for diagnosis, cure, mitigation, prevention or treatment of diseases in human beings or animals or for alternating any structure or function of the body of human being or animals. Pharmaceutical chemistry is a science that makes use of general laws of chemistry to study drugs i.e. their preparation, chemical natures, composition, structure, influence on an organism and studies the physical and chemical properties of drugs, the methods of quality control and the conditions of their storage etc. the family of drugs may be broadly classified as.

    1. Pharmacodynamic agents.

    2. Chemotherapeutic agents.

    It is necessary to find the content of each drug either in pure or single, combined dosage forms for purity testing. It is also essential to know the concentration of the drug and it’s metabolites in biological fluids after taking the dosage form for treatment.

    The scope of developing and validating analytical methods is to ensure a suitable method for a particular analyte more specific, accurate and precise. The main objective for that is to improve the conditions and parameters, which should be followed in the development and validation.

  3. Formulation and evaluation of rosiglitazone nanosuspension Download Article

    K.Hemalatha, S.Rajashekar
    • Article Type: Research Article
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    • Pages (29-43)
    • No of Download = 48

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    The main aim of this study is to formulate and evaluate Rosiglitazone Nano suspension. Nano suspensions are colloidal dispersion of Nano sized drug particles stabilized by surfactants. They can also be defined as a biphasic system consisting of pure drug particles dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1micro meter in size. Rosiglitazone is an oral rapid and short –acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enter hepatic circulation. Rosiglitazone Nano suspension was prepared by precipitation technique. After preparation of Nano suspension various characterization studies were done such as drug content, %yield, FTIR, DSC, TEM, and Invitro drug release.PVPK30,polaxomer are used as stabilizers. From the dissolution study F4 formulation which containts PVPK30 as stabilizer was considered as optimized formulation. It showed maximum drug release at 30min.FTIR and DSC studies revealed that good stability in dispersion.

  4. Analytical method development and validation for the estimation of aspirin and omeprazole using RP-HPLC method Download Article

    K.Kranthi Kiran, D.Supriya, D.Divya, D.Rani, G.Neelima Munni
    • Article Type: Research Article
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    • Pages (44-71)
    • No of Download = 114

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    A simple and selective LC method is described for the determination of Aspirin and Omeprazole in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of 30 volumes of ammonium acetate buffer, 40 volumes of acetonitrile and 30 volumes of Methanol with detection of 233 nm. Linearity was observed in the range 18-42 µg/ml for Aspirin (r2 =0.983) and 6-14 µg /ml for Omeprazole (r2 =0.970) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim. The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.

  5. A new analytical method development and validation for the simultaneus estimation of albuterol and ipratropium using RP-HPLC Download Article

    K.Kranthi Kiran, A.Sravya, B.Ramadhevi, B.Aruna, Ch.Ramadhevi
    • Article Type: Research Article
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    • Pages (72-95)
    • No of Download = 44

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    A simple and selective LC method is described for the determination of Albuterol and Ipratropium Bromide in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of 80 volumes of methanol and 20 volumes of water with detection of 239 nm. Linearity was observed in the range 36-84 µg /ml for Albuterol (r2 =0.996) and 6-14 µg /ml for Ipratropium Bromide (r2 =0.997) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim.

    The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.

  6. Method development and validation of escitalopram and estizolam in tablet dosage form by using new RP-HPLC method Download Article

    K.Kranthi Kiran, K.Krupavathi, K.Sandhya, K.Ganga Bhavani, G.Durga
    • Article Type: Research Article
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    • Pages (096-119)
    • No of Download = 55

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    A simple and selective LC method is described for the determination of Escitalopram oxalate and Etizolam in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of 30 volumes of ammonium acetate buffer, 40 volumes of acetonitrile and 30 volumes of Methanol with detection of 238 nm. Linearity was observed in the range 60-140 µg/ml for Escitalopram oxalate (r2 =0.999) and 6-14 µg /ml for Etizolam (r2 =0.996) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim.

    The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.

  7. A new analytical method development and validation for the simultaneus estimation of ibuprofen and tramadol using RP-HPLC Download Article

    K.Kranthi Kiran, K.Saritha, K.Maryrani, L.Thomas, Santhikumari
    • Article Type: Research Article
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    • Pages (120-141)
    • No of Download = 54

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    A simple and selective LC method is described for the determination of Ibuprofen and Tramadol in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of 60 volumes of Triethylamine buffer, 40 volumes of acetonitrile with detection of 227 nm. Linearity was observed in the range 50-150 µg/ml for Ibuprofen (r2 =0.983) and 50-150 µg /ml for Tramadol (r2 =0.985) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim.

    The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.

  8. A new analytical method development and validation for the simultaneus estimation of ledipasvir and sofosbuvir using RP-HPLC Download Article

    K.Kranthi Kiran M.Pharm (Ph.D),Assoc. M.Saisri, M.Priyanka, M.Subhashini, M.Manikanta
    • Article Type: Research Article
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    • Pages (142-165)
    • No of Download = 94

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    A simple and selective LC method is described for the determination of LEDIPASVIR and SOFOSBUVIR in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of Mixed Phosphate Buffer:ACN  (55:45) with detection of 213 nm. Linearity was observed in the range 60-140 µg/ml for LEDIPASVIR oxalate (r2 =0.999) and 6-14 µg /ml for SOFOSBUVIR (r2 =0.996) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim.

    The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.

  9. A new analytical method development and validation for the estimation of lenvatinib by using RP-HPLC method Download Article

    K.Kranthi kiran, N.Priyanka, M.Ramakrishna, M.V.Chendrashekar, N.Nagadhurga
    • Article Type: Research Article
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    • Pages (166-192)
    • No of Download = 47

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    A simple and selective LC method is described for the determination of Lenvatinib dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of Phosphate buffer (KH2PO4): Acetonitrile (80:20) with detection of 240nm. Linearity was observed in the range 60-140 µg /ml for Lenvatinib (r2 =0.996) for the amount of drug estimated by the proposed methods was in good agreement with the label claim.

    The proposed methods were validated. The accuracy of the methods was assessed by recovery studies at three different levels. Recovery experiments indicated the absence of interference from commonly encountered pharmaceutical additives. The method was found to be precise as indicated by the repeatability analysis, showing %RSD less than 2. All statistical data proves validity of the methods and can be used for routine analysis of pharmaceutical dosage form.

  10. Brian stroke memory impairment and treatment strategies Download Article

    K.Kishore Naidu, N.Srilakshmi, P.Mahanth
    • Article Type: Research Article
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    • Pages (193-200)
    • No of Download = 44

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    A brain stroke occurs when one of the brain parts are deprived form oxygen-rich blood due to various mechanism. Usually a brain stroke occurs when one of the arteries is blocked either because of narrowing of small arteries with in the brain or the hardening of the arteries that lead to atherosclerosis strokes can be either ischemic (85%) or Hemorrhagic (15%). Forget fullness is a common complaint among older people. Age –related memory changes are not the same thing as dementia. Preventing memory loss is by exercise regularly staying social, manage stress, get plenty of sleep and don’t smoke. Eat plenty of fruits and vegetable and take food contain antioxidant in abundance; will reduce your risk of stroke. Walking regularly is an easy to fight memory loss and also brain exercises to prevent loss and boost brainpower. Research is going no to enhance memory power in brain in patient with brain stroke.

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