Articles

  1. Casasol Sachets: Helps in Cancer-Related anorexia-Cachexia Download Article

    Govind Shukla, Nagalakshmi Yaparthy, D.Sruthi Rao, C.J. Sampath Kumar
    • Article Type: Research Article
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    • Pages (155-159)
    • No of Download = 50

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    Cancer anorexia-cachexia is a multifactorial condition defined by cytokine-associated wasting of protein and an ongoing loss of body weight and lean muscle mass leading to progressive functional impairment. Cisplatin and many anthracycline antibiotics widely used chemotherapy drug is associated with anorexia, markedly decrease patients quality of life. Cachexia complicates patient management, significantly increases the risk of morbidity and mortality, reduces the tolerance to antineoplastic therapies, and severely impinges on quality of life. Approximately two million people worldwide die annually solely from the consequences of cancer-related cachexia. Therefore, it is of paramount importance to develop essential Aminoacid formulation like Casasol Sachets blended with vitamin C,D & E that make every effort to prevent cachexia in cancer patients. This article reviews the current available scientific literature regarding the effect of Casasol Sachets in promoting immune function & as supportive therapy to prevent cachexia in cancer patients.

  2. Intercontinental journal of pharmaceutical Investigations and Research Download Article

    Vijayarangan Sivasamy, Manivannan Ekambaram, Kothai Ramalingam, Arul Balasubramanian
    • Article Type: Research Article
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    • Pages (160-164)
    • No of Download = 62

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    Anti-inflammatory activity of the ethanolic extract of Portulaca quadrifida Linn. was studied in wister rats using the carrageenan induced left hind paw edema, carrageenan induced pleurisy and cotton pellet induced granuloma model. The ethanolic extract (200 mg/kg, p.o.,) produced the inhibition of carrageenan induced rat paw edema.  It also showed an inhibitory effect on leukocyte migration and a reduction on the pleural exudates as well as reduction on the granuloma weight in the cotton pellet granuloma method. The results indicated that the ethanolic extract produced significant (P<0.001) anti-inflammatory activity when compared with the standard and untreated control.

  3. FORMULATION AND CHARACTERISATION OF TRANSDERMAL PATCHES OF PERINDOPRIL Download Article

    Humera Naaz, A.Faiza Shabnam, G. Venkataih, Dr.A.Yasodha, A.Sivakumar
    • Article Type: Research Article
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    • Pages (165-173)
    • No of Download = 98

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    Transdermal drug delivery system (TDDS) has been an increased interest in the drug administration via the skin for both local therapeutic effects on diseased skin (topical delivery) as well as for systemic delivery of drugs. The skin as a site of drug delivery, has a number of significant advantages over many other routes of drug administration, including the ability to avoid problems of gastric irritation, pH and emptying rate effects, avoid hepatic first-pass metabolism thereby increasing the bioavailability of drug, reduce the risk of systemic side effects by minimizing plasma concentrations compared to oral therapy, provide a sustained release of drug at the site of application; rapid termination of therapy by removal of the device or formulation, the reduction of fluctuations in plasma levels of drugs, and avoid pain associated with injections. The transdermal delivery can also eliminate pulsed entry into the systemic circulation, which might often cause undesirable side effects.  Main objective of formulating the transdermal system was to prolong the drug release time, reduce the frequency of administration and to improve patient compliance. In the present study, five formulations were prepared using single polymer in different ratios, along with plasticizers and penetration enhancer. Finally it was concluded that Some formulations show formation of brittle patch due to insufficient amount of polymer and in some patches texture of patch is not elegant due to plasticizer concentration for patch preparation. So by increasing concentration of polymer and plasticizer, finally formulation-5 was considered as optimized formula for preparing transdermal patch of Perindopril, where it shown best drug release profile.

  4. A review on plants act on both antidiabetic and antihyperlipidemic plants Download Article

    Srinivasa Rao Konijeti, G. Vidya Sagar, Sri Leela Movva
    • Article Type: Research Article
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    • Pages (174-183)
    • No of Download = 46

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    Since ancient times, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mentioned the use of plants in treatment of various human ailments. Medical plants play an important role in the management of diabetes mellitus especially in developing countries where resources are meager. Oral hypoglycemic agents like sulphonylureas and biguanides are still the major players in the management of the disease but there is growing interest in herbal remedies due to the side effects associated with the oral hypoglycemic agents. Herbal medicines have been the highly esteemed source of medicine throughout human history.  Hyperlipidemia has been ranked as one of the greatest risk factors contributing to prevalence and severity of coronary heart diseases. Hyperlipidemia is a condition when abnormally high levels of lipids i.e. the fatty substances are found in the blood. Hypolipidemic drugs are extensively used as prophylactic agents to prevent such atherosclerosis induced disorders. But these hypolipidemic drugs are not free from adverse effects. Many plant derivatives and domestic remedies have been screened for their hypolipidemic action. More than 70 medicinal plants have been documented to have significant hypolipidemic action. During the last decade, an increase in the use of medicinal plants has been observed in metropolitan areas of developed countries. Medicinal plants play a major role in diabetes and hypolipidemic activity. The advantages of herbal medicines reported are effectiveness, safety, affordability and acceptability, this review focus on diabeties and hyperlipidemia and the role of plants used for the treatment of diabeties and hyperlipidemia.

  5. Effect of hydrophilic polymers on solubility of some antihypertentives drugs by enhancement of solubility using solid dispersion technique Download Article

    Ch.Kishore, N.Sriram
    • Article Type: Research Article
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    • Pages (184-188)
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    The main aim of the present study is to carried out to enhance solubility of Felodipine. Felodipine.was selected as model drug and different carriers like Vitamin-E, Polyethylene Glycol 8000, Polyvinyl pyrrolidone K-30 were used in drug to carrier ratio 1:1, 1:2, 1:4 by weight respectively. Solid dispersions were prepared by physical mixing method and solvent evaporation method. Solid dispersions were evaluated by drug content, in-vitro release, FT-IR, DSC and XRD. The obtained data of solid dispersion prepared by solvent evaporation method were compared with physical mixing method. The result showed decrease in melting point change from crystalline to amorphous form and improved dissolution rate as compared to physical mixing as well as pure Felodipine. The finding of present study proposes that solid dispersion approach is beneficial in enhancing solubility of drug and bioavailability as well.

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