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  1. Floating microspheres: Research article Download Article

    C.H Archana, S.Divya, P.Pravalika, V.Haritha, N. Sriram
    • Article Type: Research Article
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    • Pages (99-110)
    • No of Download = 63

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    Gastric emptying is a complex process, one that is highly variable and makes in vivo performance of drug delivery systems uncertain. A controlled drug delivery system with prolonged residence time in the stomach can be great practical importance for drugs with an absorption window in the upper small intestine. The main limitations are attributed to the inter- and intra-subject variability of gastrointestinal (GI) transit time and to the non-uniformity of drug absorption throughout the alimentary canal. Floating drug delivery systems are useful in such applications. Floating microspheres have been gaining attention due to the uniform distribution of these multiple-unit dosage forms in the stomach, which results in more reproducible drug absorption and reduced risk of local irritation. The present research briefly addresses the physiology of the gastric emptying process with respect to floating drug delivery systems. Floating microsphere were prepared by solvent evapouration method, using hydroxylpropyl methylcellulose (HPMC), ethyl cellulose (EC), Eudragit S 100 polymer in varying ratios. The shape and surface morphology of the microspheres were characterised by differential scanning calorimetry and scanning electron microscopy.

  2. Anti microbial activity of aqueous and ethanolic extracts of roots and leaves of murraya koenigii Download Article

    A.Mounika, G.K.Sree Lakshmi, M.Bheemeshwar, M.Yashaswi, N.Sri Vidya Jahnavi
    • Article Type: Research Article
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    • Pages (111-118)
    • No of Download = 96

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    Murraya koenigii, family Rutaceae, commonly known as Curry leaf plant is a highly valued plant for its medicinal value and characteristic aroma.The plant shows varied pharmacological activities like antimicrobial, antifungal,hypoglycemic,antiobese,antipyretic,hepatoprotective etc., The plant is a rich source of carbazole alkaloids containing mahanimbine as a major alkaloidal constituent in its major proportion which was proved by mayer’s alkaloidal test. The aqueous and ethanolic extracts of roots and leaves of the plant were screened for antimicrobial activity for Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli.The antimicrobial activity was tested by diffusion assay method in which cup plate method was chosen. The study shows that aqueous and ethanolic root and leaf extracts possess remarkable antimicrobial activity when compared with standard cephalosporin. Thus,Murraya Koenigii shows tremendous antimicrobial activity with root and leaf extracts.

  3. Development and evaluation of a novel twice daily cup core metformin hydrochloride tablet formulation Download Article

    Sravanthi Todasam and Nagarajan Srinivasan
    • Article Type: Research Article
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    • Pages (119-128)
    • No of Download = 48

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    The study was undertaken with an aim to formulate develop and evaluation of a novel twice daily core cup of Metformin hydrochloride(Antidiabetic drug) tablets using different grades and weight of HPMC polymers as release retarding agent.  Granules were evaluated for tests Bulk density, tapped density, Hausner ratio before being punched as tablets. Tablets were tested for weight variation, thickness, hardness and friability as per official procedure.   F-2 was found to be 73.90. From the above results and discussion it is concluded that formulation of Cup core tablet of containing Metformin hydrochloride HPMC K 4M & 215: 230 (in mg) can be taken as an ideal or optimized formulation of sustained release tablets for 12hour release as it fulfills all the requirements for sustained release tablet and our study encourages for the further clinical trials on this formulation. The core in cup tablets of Metformin hydrochloride were prepared by wet granulation method, they were evaluated for weight variation, friability, hardness, and thickness for all batches (F1 – F9). No significant difference was observed in the weight of individual tablets from the average weight. The weight variation tests were performed according to the procedure given in the pharmacopoeia. In a weight variation test, pharmacopoeial limit of tablet for percentage deviation is 5%. The average percentage deviation of all tablet formulation was found to be within the pharmacopoeial limit and hence all formulation passed the test for uniformity of weight.

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