Articles

  1. Hair repairTM: Nutritional support to inhibit DHT naturally and nourishes the follicles of hair Download Article

    Govind Shukla, Jyothika Vanamali, C J Sampath Kumar
    • Article Type: Research Article
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    • Pages (59-63)
    • No of Download = 162

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    Beautiful hairs are not just about looks, it is a sign of excellent general health as well as good hair care practices. Hair is composed primarily of proteins. It is made of three layers, the medulla, cortex, and cuticle. Damaged hair is caused by many factors such as excessive heat styling. It is characterized internally by open cuticles and broken protein bonds. Physically, damaged hair is rough, brittle to the touch, and prone to split ends. Many chemicals such as bleaches, perms, and relaxers damage hair greatly. In order for them to work they must swell hair's cuticle. This process roughens cuticle, making it prone to chipping and breaking off. These chemicals also wear down protein bonds in hair--the very thing that keeps our hair strong and lustrous. Hair repair is an intensive hair repair formula for men & women, towards strengthening hair & promoting hair growth. Hair repair tablet contains Sawpalmetto extract, Betasito sterols, Stinging nettle extracts that are powerful DHT (DihydroTestosterone) inhibitors effective for the treatment of Androgenic Alopecia. Where as DL- methionine & N-acetyl cysteine retains hair luster, prevents Alopecia as well as hair follicle cell apoptosis. Biotin & Vit B12 regenerates RBC which is vital for healthy hair; zinc prevents Dandruff & boosts hair regeneration. Copper helps as pigmenting factor for hair, PABA (para amino benzoic acid) restores grey hair to its original color.

  2. Effervescent technique in development of floating tablets for antiviral drugs Download Article

    Ch.Kishore, N.Sriram
    • Article Type: Research Article
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    • Pages (64-68)
    • No of Download = 26

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    The purpose of this investigation was to prepare a regiospesific drug delivery system of Stavudine. Floating tablets of Stavudine were prepared by direct compression method employing different concentration of HPMC K15M by effervescent technique. Sodium bicarbonate was incorporated as a gas-generating agent. The floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, swelling studies, in vitro buoyancy and dissolution studies. The effect of different concentration of HPMC K15M on drug release profile and floating properties was investigated. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for more than 12 hours. Increased in the HPMC K15M level, decreased the floating lag time but tablets floated for longer duration. The formulation with 1:1 drug: Polymer ratios were found to float for longer duration as compared with other formulations containing HPMC K15M. The drug release from the tablets was sufficiently sustained and non-Fickian transport of the drug from tablets was confirmed.

  3. Stability indicating RP-HPLC method for estimation of dapagliflozin in bulk and tablet dosage form Download Article

    Jeyabaskaran M, Prof. Rambabu C, Lakshmi Maneka S
    • Article Type: Research Article
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    • Pages (69-78)
    • No of Download = 9

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    A simple, specific, accurate, precise and stability-indicating reverse phase high performance liquid chromatography (RP-HPLC) method is developed for estimation of Dapagliflozin (DGF) in bulk and Pharmaceutical dosage form. The method employed, Hypersil BDS C18 250 mm x 4.6 mm, 5 mm column in isocratic mode with mobile phase of 0.1% Ortho phosphoric acid buffer and acetonitrile 50:50% v/v. The flow rate was 1.0 mL min-1 and effluent was monitored at 245 nm using PDA detector. The injection volume was 10 µl and the total runtime was set as 5min. The retention time for DGF was found to be 2.226min.The method was validated in terms of Linearity, accuracy, precision, limit of detection (LOD), limit of quantification (LOQ) etc. in accordance with ICH guidelines. Linear regression analysis data for the calibration plot showed that there was a good linear relationship between response and concentration in the range of 25 - 150 µg/ml respectively. The LOD and LOQ values for HPLC method were found to be 0.04 and 0.121 µg/ml respectively. No chromatographic interference from the tablet excipients was found. The proposed method was successfully used for estimation of Dapagliflozin (DGF) in Bulk and Pharmaceutical dosage form.               

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